Denver Broncos head coach Josh McDaniels has ruled right tackle Ryan Harris and running back Knowshon Moreno out for Sunday's game against the Indianapolis Colts.

Harris has not played yet during the regular season, and was limited during Wednesday's practice with an ankle injury. Harris did not participate on Thursday, and 2010 second-round pick Zane Beadles will get the start at right tackle.

Moreno being ruled out comes as bit of a surprise.

Denver's leader in rushing yards (111), yards from scrimmage (182), and touchdowns (2), Moreno has not appeared on any of the team's injury reports this week. With Moreno out, running backs Correll Buckhalter will play a larger role in the offense, which could also see the debut of Laurence Maroney.

Update: Moreno was injured during Friday's practice.